Additive effect, which increases risk of QT prolongation and de pointes. P-glycoproteins act as energy-dependent transmembrane efflux pumps that play a role in the distribution of medications such as … Effect of amiodarone on serum quini-dine and procainamide levels. Please sign into you HealthSavvy account. Dangerous interaction between amiodarone and quinidine. 2003;68:2189-2196.7. Serum digoxin concentrations can increase by up to 104%. These medications may cause some risk when taken together. Circulation. Concomitant administration with ritonavir and nelfinavir is contraindicated. Drug Interactions With Amiodarone Article Continues on Next Page >. Monitor for GI, neurologic, and cardiac toxicities. Interactions between grapefruit juice and cardiovascular drugs. Amiodarone can inhibit P-glycoprotein expression, which results in supratherapeutic levels of agents absorbed via this pathway. There are 10 disease interactions with amiodarone which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Tartini R, Kappenberger L, Steinbrunn W, Meyer UA. Delayed onset. Please enable it to take advantage of the complete set of features! The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Cimetidine-amiodarone interaction. This site does not dispense medical advice or advice of any kind. Delayed onset. See current texts and reviews for further information. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts. Transporter proteins. Monitor cardiac function if concurrent use of 5-HT. Withhold amiodarone for 5 half-lives before and 4 hours after administering ibutilide. The interval between pre- and post-amiodarone serum digoxin levels ranged from five days to nine months (mean interval, seven weeks). Amiodarone (Cordarone) is a complex antiarrhythmic agent with multiple electrophysiologic effects, unusual pharmacokinetics, and numerous potentially harmful drug interactions … Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Increased amiodarone levels. American Heart Association. Nexterone [package insert]. Medications that cause a certain change in the heart rhythm known as QT prolongation. Usually avoid combinations; use it only under special circumstances. Table 1 -Amiodarone and CV agents: examples of clinically significant interactions* (continued), Dofetilide, ibutilide, torsades quinidine, sotalol. Am FamPhysician. Effect of phenytoin on the clinical pharmacokinetics of amiodarone. Amiodarone has the following interaction information: Acebutolol. USA.gov. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. HHS It can be given by mouth, intravenously, or intraosseously. Decrease warfarin dose by 20% to 30%. 2004;4:281-297.36. Significant increase in INR. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Side effects, drug interactions, dosage, and pregnancy safety information is included. Ann Intern Med. 1994;24:707-714.13. Avoid combinations; the risk of the interaction outweighs the benefit. The mean (± SD) pre-amiodarone serum digoxin level was 1.0±0.4 ng/ml, and the post-amiodarone serum digoxin level was … In addition, a baseline chest radiograph and eye examination should be performed. There are a number of important drug interactions with amiodarone. 1988;28:909.30. Kahn JB. Saal AK, Werner JA, Greene HL, et al. Sanoski CA, Bauman JL. 4. Arch Intern Med. All rights reserved. Table 3 -Amiodarone and GI agents: examples of clinically significant interactions*. Data sources include IBM Watson Micromedex (updated 1 Oct 2020), Cerner Multum™ (updated 1 Oct 2020), Wolters Kluwer™ (updated 30 Sep 2020) and others. Select one or more newsletters to continue. NLM Part 7.2: Management of cardiac arrest. 2002;121:19-23.8. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. This interaction occurs when the pharmacologic response to a given agent is changed by the actions of another drug.2 An example of this type of interaction would be 2 drugs that produce additive effects. Liberman BA, Teasdale SJ. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. 2005;115:S1-S13.26. Breast-feeding is not recommended while using this drug. Sign Up to Receive Our Free Coroanvirus Newsletter, SELECTED ANTIARRHYTHMICS/AMPRENAVIR; FOSAMPRENAVIR, WEAK CYP3A4 INHIBITORS/LOMITAPIDE (>40MG), SELECTED CLASS I & CLASS III ANTIARRHYTHMIC AGENTS/SOTALOL, AMIODARONE/LOVASTATIN (> 40 MG); SIMVASTATIN (> 20 MG), CLASS IA AND III ANTIARRHYTHMICS/DISOPYRAMIDE, CLASS IA AND III ANTIARRHYTHMICS/IBUTILIDE, SELECTED CLASS IA AND III ANTIARRHYTHMICS/PROPAFENONE, SELECTED QT PROLONGING AGENTS/ZIPRASIDONE, CLASS IA AND CLASS III ANTIARRHYTHMICS/DOFETILIDE, SELECTED CLASS I & III ANTIARRHYTHMICS/MIZOLASTINE, CLASS I AND III ANTIARRHYTHMICS/HALOFANTRINE, CLASS IA & III ANTIARRHYTHMICS/SELECTED QUINOLONES, CLASS IA AND III ANTIARRHYTHMIC AGENTS/FINGOLIMOD, QT PROLONGING AGENTS/ARTEMETHER-LUMEFANTRINE, SELECTED CLASS IA & III ANTIARRHYTHMICS/CISAPRIDE, SELECTED ANTIARRHYTHMICS/QUINUPRISTIN-DALFOPRISTIN, AMIODARONE; DRONEDARONE/RIFAMPIN; RIFAPENTINE, AMIODARONE;DRONEDARONE/CARBAMAZEPINE;PHENOBARBITAL;PHENYTOIN, P-GLYCOPROTEIN (P-GP) INHIBITORS/ORAL LEFAMULIN, P-GLYCOPROTEIN (P-GP) INHIBITORS/TALAZOPARIB, STRONG AND MODERATE CYP2C9 INHIBITORS/BOSENTAN, SELECTED P-GLYCOPROTEIN (P-GP) INHIBITORS/BETRIXABAN, P-GLYCOPROTEIN (P-GP) INHIBITORS/COLCHICINE, CLASS IA & III ANTIARRHYTHMICS/ELIGLUSTAT, CLASS IA & III ANTIARRHYTHMICS/BUPRENORPHINE, CLASS IA AND III ANTIARRHYTHMICS/VARDENAFIL, AMIODARONE; DRONEDARONE/DIGITALIS GLYCOSIDES, AMIODARONE/SOFOSBUVIR + SELECTED DIRECT ACTING ANTIVIRALS, P-GP INHIBITORS THAT PROLONG QT/LEFAMULIN, SELECTED MODERATE CYP2C9 INHIBITORS/SIPONIMOD, QT PROLONGING AGENTS/INOTUZUMAB OZOGAMICIN, SELECTED P-GLYCOPROTEIN (P-GP) INHIBITORS/VENETOCLAX, WEAK CYP3A4 INHIBITORS/LOMITAPIDE (>30MG OR <=40MG), SELECTED CLASS IA & III ANTIARRHYTHMICS/SELECTED QUINOLONES, QT PROLONGING AGENTS/TRAZODONE (>= 100 MG), CLASS I & CLASS III ANTIARRHYTHMICS/VERNAKALANT, AGENTS THAT AFFECT IODIDE/RADIOACTIVE IODIDE, P-GLYCOPROTEIN (P-GP) INHIBITORS/TOPOTECAN, SELECTED P-GLYCOPROTEIN (P-GP) INHIBITORS/DABIGATRAN, SELECTED WEAK CYP2D6 INHIBITORS THAT PROLONG QT/TAMOXIFEN, P-GP OR BCRP INHIBITORS THAT PROLONG QT/PAZOPANIB, SODIUM CHANNEL BLOCKER; POTASSIUM CHANNEL BLOCKER/LACOSAMIDE, QT PROLONGING AGENTS/TRAZODONE (< 100 MG), WEAK CYP3A4 INHIBITORS/LOMITAPIDE (<=30MG), SELECTED P-GP AND WEAK CYP3A4 INHIBITORS/RIVAROXABAN, CLASS IA & III ANTIARRHYTHMICS/TOLTERODINE, AMIODARONE; DRONEDARONE/SELECTED BETA-BLOCKERS, SELECTED ANTIARRHYTHMICS/SELECTED PROTEASE INHIBITORS, SELECTED WEAK CYP3A4 INHIBITORS THAT PROLONG QT/TACROLIMUS, P-GLYCOPROTEIN (P-GP) INHIBITORS/AFATINIB, CYP3A4; CYP2C8; P-GLYCOPROTEIN (P-GP) INHIBITORS/LOPERAMIDE, AMIODARONE/ATORVA; LOVA (<=40MG); SIMVASTATIN (<=20MG), SELECTED CYP2C9 INHIBITORS/SELECTED NSAIDS.
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